Retatrutide – 5mg

1. GLP-1 and GIP Receptor Activation

Like semaglutide and tirzepatide, Retatrutide acts onglucagon-like peptide-1 (GLP-1)andglucose-dependent insulinotropic polypeptide (GIP)receptors. These actions have been shown to influence:

• Enhanced satiety signaling
• Delayed gastric emptying
• Reduced caloric intake
• Improved glucose tolerance

Animal models suggest this dual incretin mechanism helps stabilize blood glucose while significantly lowering energy consumption.

2. Glucagon Receptor Stimulation

The most notable distinction of Retatrutide lies in itsglucagon receptor agonism, which promotes:

• Increased basal metabolic rate
• Lipolysis and breakdown of hepatic glycogen stores
• Enhanced thermogenesis in brown adipose tissue

This sets it apart from earlier-generation GLP-1 drugs, enabling researchers to evaluatetotal energy balance shifts—a balance ofdecreased intake and increased expenditure.

3. Weight Loss and Obesity Modeling

In clinical-stage trials, Retatrutide has demonstratedunprecedented reductions in total body weight—up to 24%over multi-week administration periods in obese models. This magnitude of change is driving its popularity in obesity research settings, particularly when studying resistant adiposity or endocrine-related metabolic dysfunction.

4. Synergistic Hormonal Modulation

Studies suggest Retatrutide’s effects may also extend to downstream hormonal networks including leptin, insulin, and adiponectin pathways. Researchers are exploring its role in:

• Fatty liver disease models
• Cardiometabolic inflammation
• Neuroendocrine signaling related to hunger and reward

• Unreconstituted: Store at -20°C in a sealed, light-protected container
• Reconstituted: Use within recommended timeframes at 2–8°C
• Reconstitute using bacteriostatic water or other lab-approved diluents per experimental protocol. Avoid exposure to direct light and moisture.

This compound is intended strictly for scientific research, laboratory modeling, and in vitro experimentation. Retatrutide is not approved for human or veterinary use, and must only be handled by qualified research personnel under appropriate lab conditions.

All True Science Peptides products are independently verified by third-party laboratories using HPLC and Mass Spectrometry, and each batch includes a Certificate of Analysis to ensure integrity and purity.