What Is Melanotan 2 (MT-2)?
Melanotan 2 mimics the function of human α-MSH, a peptide hormone that influences pigmentation and multiple neuroendocrine functions. Initially designed as a sunless tanning agent, MT-2 was found to exert a range of effects including:
- Enhanced sexual arousal
- Increased skin pigmentation and tanning
- Appetite suppression
- Modulation of compulsive behaviors and addiction
- Reduced glucagon secretion
- Potential reversal of autism-related features in early development
Melanotan 2 Research
Melanocortin Receptor Binding
MT-2 acts primarily by binding to melanocortin receptors, a family of five G protein-coupled receptors with distinct biological functions:
- MC-1R: Expressed on melanocytes, activation causes skin and hair darkening through increased melanin synthesis.
- MC-2R: Located in the adrenal glands, stimulation promotes secretion of adrenal hormones such as cortisol.
- MC-3R: Implicated in appetite control and energy regulation; MT-2 binds weakly to this receptor.
- MC-4R: Influences feeding behavior, sexual function (including male erectile function), and energy homeostasis.
- MC-5R:Found on sweat glands and pancreatic islet cells; involved in sweat secretion and possibly metabolic regulation.
Safety and Usage Notes
MT-2 research focuses on neuroendocrine and dermatologic pathways. As a potent modulator of multiple melanocortin receptors, it requires careful handling in research contexts. This peptide is intended for laboratory research use only and is not approved for human consumption or therapeutic use.