NAD+ – 500mg

1. High-Dose NAD+ and Energy Metabolism
   Increased concentrations of NAD⁺ are commonly used to investigate ATP generation, mitochondrial function, and reactive oxygen species balance. Research involving high-dose NAD⁺ shows improved cellular respiration and greater resistance to bioenergetic stress in experimental models.
2. Sirtuins and Epigenetic Regulation
   Higher NAD⁺ levels can more significantly impact sirtuin-mediated gene expression and histone deacetylation, which are important in aging, inflammation resolution, and metabolic adaptation. SIRT1 activation is dose-responsive, and larger NAD⁺ quantities allow sustained activity in complex in vitro protocols.
3. DNA Integrity and Repair Enzymes
   500mg NAD⁺ doses are ideal for experiments exploring PARP activity and DNA damage response systems, especially in high-throughput genomic studies. NAD⁺ is essential for the poly(ADP-ribosyl)ation process that protects against oxidative genomic insult.
4. Neurovascular and Muscular Resilience
   Research shows that NAD⁺ supports both neuronal function and vascular tone in aging-related models. High-dose administration has been associated with better maintenance of synaptic integrity and vascular compliance, which is relevant for investigations into neurodegeneration and endothelial dysfunction.
5. Combinatory Use in Advanced Experimental Design
   500mg NAD⁺ is often used in tandem with research compounds such as:

• Resveratrol and Pterostilbene – for sirtuin coactivation
• CoQ10 and alpha-lipoic acid – for mitochondrial synergism
• Niacinamide, NMN, NR, and B-complex vitamins – for NAD⁺ precursor conversion and salvage pathway analysis

• Unreconstituted: Store at -20°C in a sealed, light-protected container
• Reconstituted: Use within recommended timeframes at 2–8°C
• Handle with precision to avoid cross-contamination. Reconstitute with sterile, lab-approved diluent according to protocol. Use calibrated lab equipment for proper dosage control at higher concentrations.

This compound is intended strictly for scientific research, in vitro study, and preclinical applications. NAD⁺ is not for human or veterinary use. All use must occur under qualified supervision in a properly credentialed research environment.

All True Science Peptides compounds are validated through third-party HPLC and Mass Spectrometry analysis and are accompanied by batch-specific Certificates of Analysis.