Kisspeptin – 10mg

1. Gonadotropin Signaling and Hormonal Pulsatility
   Kisspeptin-10 has been shown to drive secretion of GnRH, thereby indirectly regulating LH (luteinizing hormone) and FSH (follicle-stimulating hormone) release from the anterior pituitary. Animal and human models indicate a dose-dependent increase in testosterone levels following kisspeptin-10 administration in males, with implications for research in puberty onset, fertility, and hormonal rhythm regulation.
2. Testosterone Modulation
   In controlled research, kisspeptin-10 administration in males has resulted in significant increases in serum testosterone within 90 minutes. These effects appear to be sex-specific, with minimal testosterone response in females. Preclinical data suggest kisspeptin may influence LH pulsatility and timing, offering a route to better understand hormonal entrainment and synchronization.
3. Energy Balance and Metabolic Feedback
   Kisspeptin expression is tightly coupled to energy status, with under-nutrition and obesity both impacting its function. Genetically modified mice lacking the kisspeptin receptor (Kiss1r) exhibit increased adiposity and decreased energy expenditure. This evidence supports ongoing studies into the peptide’s dual role in regulating both metabolism and reproductive viability.
4. Cancer Metastasis Suppression
   Originally named “metastin,” kisspeptin was first identified for its ability to suppress melanoma metastasis by up to 95%. It has since been implicated in reducing cancer cell migration, adhesion, and invasiveness. Lower levels of kisspeptin expression have been documented in aggressive forms of breast, bladder, GI, ovarian, pancreatic, prostate, skin, and thyroid cancers, pointing to its potential role as a tumor suppressor peptide in metastatic models.

• Unreconstituted: Store at -20°C in a sealed, light-protected container
• Reconstituted: Use within recommended timeframes at 2–8°C
• Reconstitute with sterile bacteriostatic water or lab-approved diluent. Handle under sterile laboratory conditions.

This compound is intended strictly for scientific research, in vitro study, and preclinical modeling. Kisspeptin-10 is not approved for human or veterinary use and must be handled by qualified personnel in a controlled research environment.

All True Science Peptides compounds undergo third-party purity validation via HPLC and Mass Spectrometry and are shipped with batch-specific Certificates of Analysis.