What Are BPC-157, TB-500, and GHK-Cu?
BPC-157 is derived from a protective protein found in gastric juice. It has been shown in preclinical studies to modulate nitric oxide signaling, upregulate VEGFR2 and growth hormone receptors, and accelerate healing in tendon, ligament, GI, and nerve tissues. It also plays a role in reducing pro-inflammatory cytokines and promoting vascular repair.
TB-500 is a bioactive peptide sequence of Thymosin Beta-4 that sequesters actin, enabling rapid cell migration and cytoskeletal remodeling. It is known to activate PI3K/Akt, Notch, and TGF-β repair pathways, facilitating wound healing, progenitor cell recruitment, and angiogenesis.
GHK-Cu (glycyl-L-histidyl-L-lysine with copper) is a naturally occurring copper peptide known for its ability to stimulate collagen production, repair dermal tissue, promote hair follicle activity, and act as a potent antioxidant. It influences over 4,000 genes linked to tissue remodeling, stem cell activation, and inflammation modulation.
Synergistic Effects in Tissue Regeneration
Multi-Pathway Healing Synergy:
- Angiogenesis : BPC-157 and TB-500 promote VEGF-mediated blood vessel growth; GHK-Cu enhances endothelial proliferation and reduces tissue hypoxia.
- Actin-Driven Cell Migration : TB-500 regulates actin polymerization for cellular mobility, while BPC-157 boosts actin gene expression—both crucial for fibroblast and immune cell migration.
- Gene Expression & Remodeling : GHK-Cu affects ECM, collagen, and metalloproteinase regulation. It pairs with BPC-157 and TB-500 to reduce fibrosis and enhance structural tissue integrity.
- Inflammation Control : All three peptides contribute to a reduction in oxidative stress, cytokine signaling, and NF-kB pathway activation, making the blend ideal for chronic injury models.
Applications in Research
- Connective tissue and joint regeneration
- Soft tissue wound and burn recovery
- Fibrosis and scar tissue reduction
- Hair follicle regeneration and skin aging models
- Neurorepair and angiogenesis pathways
- Antioxidant and anti-inflammatory peptide research