NAD+ – 100mg

1. Energy Metabolism and Mitochondrial Function
   NAD⁺ is a required coenzyme for oxidative phosphorylation and ATP production in mitochondria. In vitro and in vivo models demonstrate that enhanced NAD⁺ levels can improve mitochondrial efficiency, cellular respiration, and muscle endurance. Preclinical models have associated NAD⁺ replenishment with enhanced metabolic rate and lean mass retention.
2. Sirtuin Activation and Epigenetic Modulation
   As a substrate for sirtuins (SIRT1–SIRT7), NAD⁺ is involved in gene regulation, histone deacetylation, and DNA repair mechanisms. These pathways are critical to studies of cellular aging, stem cell maintenance, and inflammatory signaling. NAD⁺'s relationship with SIRT1, in particular, has made it a focal point in models of caloric restriction and metabolic longevity.
3. DNA Repair and Genomic Stability
   NAD⁺ also fuels PARP (poly ADP-ribose polymerase) enzymes, which play a role in genome maintenance. PARPs are involved in base excision repair pathways and oxidative DNA damage repair. Decreased NAD⁺ levels have been observed to impair these protective systems in cellular aging models.
4. Neurological and Vascular Function Studies
   NAD⁺ has been shown to support neuronal viability, synaptic integrity, and blood vessel elasticity in animal research. Models involving cognitive aging and ischemia have explored how NAD⁺ supplementation may protect central nervous system cells and smooth muscle tissues, including studies examining blood pressure regulation and neurovascular signaling.
5. Synergistic Pairing in Research Protocols
   NAD⁺ has demonstrated additive or synergistic effects in experimental use when paired with molecules such as:

• Resveratrol (SIRT1 activator)
• Coenzyme Q10 (electron transport chain cofactor)
• Biotin and B-complex vitamins (NAD+ salvage pathway support)
• Alpha-lipoic acid, creatine (cellular energetics and antioxidant reinforcement)

• Unreconstituted: Store at -20°C in a sealed, light-protected container
• Reconstituted: Use within recommended timeframes at 2–8°C
• Avoid moisture and prolonged exposure to light. Reconstitute with sterile, lab-grade diluent as specified in protocol.

This compound is intended strictly for scientific research, in vitro experimentation, and controlled preclinical investigations. NAD⁺ is not approved for human or veterinary use. All research must be conducted by qualified professionals in accredited laboratory environments.

All True Science Peptides compounds are validated by third-party HPLC and Mass Spectrometry and include batch-specific Certificates of Analysis for purity and identity.